Protandim is a premier NRF2 Activator. In 2004, Myhill approached Dr. McCord, an expert in antioxidants and free radical diseases, to review and improve a nutritional supplement formula that would increase the level of antioxidants superoxide dismutase (SOD), catalase, and glutathione peroxidase in the human body. Myhill had created a core botanical composition of ingredients, as well as options to include numerous other supporting ingredients, that he believed could increase the level of antioxidants in our body and also provide other benefits. Using that information, Myhill and Dr. McCord created Protandim from a list of 41 potential ingredients. Dr. McCord suggested that they work with 8 of the original ingredients. After further research and testing, Dr. McCord further suggested reducing the ingredients to the five currently used in Protandim to ensure the safety of the product and reduce potential side effects. The five ingredients in the final product were specific quantities of milk thistle, bacopa, ashwagandha, green tea and turmeric which ultimately became known as Protandim.
While Paul Myhill initially had the leading role in creating Protandim and is the inventor on its patents, Myhill has always recognized the significant contributions of Dr. McCord in refining, testing, and developing Protandim, including in several public statements.